Metabolic Relationships of Dis-ease

The following is a brief discussion of some of the aspects of the fundamental biochemical pathways concerning the primary metabolic relationships that are pivotal points of the body’s ability to heal. They consist of patterns which relate to digestion and assimilation; reproductive function and neurotransmitter metabolism; and neurologic function, cell membrane integrity and nutrient delivery. The following metabolic relationships are classified according to specific organs and physiologic functions or biochemical processes.

Pattern 1: Protein and it's Effect on Superoxide Production

Too much protein ingestion, or poor protein digestion, can lead to putrefaction and bacterial imbalance of the colon resulting in nitrite (N03) production. N03 is absorbed into the portal circulation, in turn, causing oxidation of hemoglobin to methemoglobin (the iron being in the ferric state). Thus, when the oxygen comes in contact with the iron, it simply gives up its electron resulting in a superoxide radical and hemoglobin which is incapable of combining with oxygen. “Normal" individuals can have up to 10% methemoglobin; 10 to 20% methemoglobin results in cyanosis. Certain poisons and drugs, esp. sulfonamide drugs and other antibiotics, result in the same imbalance. Conditions associated with poor protein digestion include:

Pattern 2: Low CO2

Certain proteins (i.e., those which contain steroids or stimulate steroid production) cause excessive protein turnover which decreases the blood C02 levels. This results in poor protein digestion as CO2 is necessary for HCl production. This pattern is also seen with excessive or prolonged mental, emotional or physical stress resulting in, or leading toward, hyperventilation symptomatology. Hyperventilation, angina and myocardial infarction are basically the same biochemical response to low C02 and tissue calcium. The difference being the hyperventilation patient has adequate coronary circulation and the cardiac patient does not due to compromised liver/gallbladder function. Whether from too much protein or too much stress, low C02 seems to be the initiating factor in all the above situations. Conditions associated with excessive steroidal production in relation to protein anabolism (growth) include:

Pattern 3: Breath as it Relates to Hemoglobin Production

As much as 90% of the protein requirement of an adult is for maintaining hemopoetic function. Three million erythrocytes/900 trillion molecules of hemoglobin are broken down every second by the spleen and macrophage cells as they are responsible for protecting the body’s functioning proteins. This process is dependent on the interstitial free fluid pressure functioning at a sub atmospheric pressure of -3 mm Hg. It is the sub-atmospheric pressure caused by lymphatic flow which causes fluid to move from the capillaries into the extracellular fluid spaces and then into the lymph channels. It is the movement of the lung (breath) which maintains the negative pressure of the lymphatic channels and cranium. Therefore, breath is especially important for any pattern relating to spleen or immune function. Conditions associated with ineffectual breath and impaired oxygenation and lymphatic include:

Pattern 4: Cell membrane (nutrient delivery) health

The liver is the primary anabolic organ. Even though it has a hand in most physiologic functions of the body, its basic strength comes from its ability to unsaturate fatty acids. Unsaturated fatty acids are a primary factor concerning cell membrane permeability and polarization. Membrane polarization plays a primary role in what is communicated between the internal and external environments of the cell; the cellular membrane is “the nervous system" of the cell. One of the primary factors influencing membrane polarization is the movement of molecules, esp. O2 and OH molecules, through the cell membrane which create electrical potentials. Fried foods and oils exposed to excessive heat cause the cell membrane to become hyper-permeable resulting in a “leaky" condition which results in a loss of cellular polarity and production of peroxide radicals. This results in poor nutrient delivery, inadequate oxygenation and the inability to detoxify on a cellular level. Other issues may include inadequate phospholipid and prostaglandin production resulting in prolonged inflammatory responses. Conditions which may be associated with ineffective lipid metabolism include:

Pattern 5: Inflammatory Responses

We use carbohydrates for the first ninety minutes after mealtime. After that, most of the excess carbohydrates, whether from refined or complex sources, are converted to saturated fats and cholesterol via pyruvic acid. Thus, the metabolism is geared toward making fats and cholesterol resulting in (1) a compromised ability to use fats for energy; (2) an increase in bile concentration which can eventually lead to liver and gallbladder congestion; (3) increased sterols in cellular membranes which decreases cell membrane permeability; and (4) prolonged inflammatory responses and diseases. Conditions associated with excessive carbohydrate metabolism include: /

Pattern 6: Hyperglycemic Insult

A rise in blood proteins, amino acids and lipids trigger an insulin release much like the release associated with a rise in blood glucose levels. Once released, insulin causes most cells to become more permeable to glucose, amino acids, lipids, electrolytes and other nutrients. Unfortunately, continued and excessive insulin requirements can lead to a number of blood sugar related diseases as the body is not designed to rely primarily on insulin for nutrient delivery. Rather, enzymatic (cellulase) and nutrient rich foods which contain moderate amounts of proteins, fats and carbohydrates should be responsible for nutrient delivery and assimilation. Conditions associated with inadequate dietary polysaccharides and cellulases include:

Hormonal and Neurotransmitter Metabolism

Pattern 7: Hyperglycemic Effects on the CNS

The less light we are exposed to, the greater the production of melatonin from serotonin which results in a decrease in serotonin. As serotonin is responsible for appetite suppression and positive emotional responses, a decrease in serotonin causes an increase in appetite and frequently sugar cravings. After eating, insulin is secreted which pulls sugar and amino acids into the cells (not the CNS). Tryptophan is less effected by insulin and moves into the CNS where it is converted to serotonin and the cycle stops...for a moment. Conditions associated with impaired neurotransmitter metabolism include:

Pattern 8: Impaired Cholesterol Metabolism as it Relates to Reproductive Hormones

The functions of the gallbladder (i.e., concentrating bile and cholesterol) are directly related to the cellular mechanisms which influence hormone production (cholesterol being the starting point of the steroidal hormones). However, if the cellular physiology is geared toward making cholesterol (typically from consuming too many carbohydrates and/or saturated fats) and not efficiently utilizing cholesterol for the production of steroidal hormones, hormone production may be impaired. Hormone production of both males and females basically follow the same pathways; however, cholesterol and lipid metabolism are the controlling aspects concerning the female hormones, whereas blood proteins are the controlling aspect concerning the male hormones. The basic hormonal pathway is: Cholesterol ---> Progesterone ----> Testosterone ---> Estrogen

Conditions associated with impaired cholesterol metabolism include:

Pattern 9: Impaired Phospholipid Metabolism

High blood sugar, whether from excessive carbohydrate intake or other hyperglycemic issues, causes a push towards cholesterol production at the expense of phospholipids (i.e., lecithins). This results in inadequate production of surfactant (a phospholipid lubricant) resulting in asthma, bronchitis, and other respiratory conditions. Again, Conditions associated with inadequate surfactant production include:

Pattern 10: Colon Toxicity Directly Effecting White Blood Cells and reproductive Health

The colon is a primary factor in overall vitality of an individual. Just one of the issues that can cause so many “seemingly" unrelated conditions is the fact that fluid and associated toxins are absorbed from the colon into the portal circulation. From there, toxins go to the liver and uterus. In turn, the liver cannot detoxify effectively by way of the gallbladder - small intestine - colon pathway if the colon itself is already toxic. This causes a toxic condition which can interfere with ovulation, as well as cause “hypersensitive" responses of the white blood cells often associated with autoimmune diseases. The germinal tissue, bone marrow, blood cells and viral issues can all be effected by this pattern. Conditions associated with colon toxicity include:

Pattern 11: Blood Protein / Thyroid and Anterior Pituitary ---> Lg. Intestine (iodine metabolism)

The thyroid is responsible for increasing virtually all metabolic functions. It is a key factor in genetic expression and especially maturation (i.e. diencephalon and puberty); it is the thyroid hormone which is responsible for a tadpole becoming a frog. Excessive blood proteins, especially in combination with refined, starchy or excessively cooked carbohydrates causes twice the insulin response resulting in hypoglycemia and sluggish metabolic states. This not only puts direct stress on the thyroid, but dense, hard to digest protein also creates a toxic colon as well. This results in nitrite formation which interferes with iodine metabolism, thus causing greater blood sugar fluctuations. This is also a primary pattern concerning testosterone as blood proteins are a primary influence on the male hormones. Another factor in thyroid conditions is poor sleep habits (staying up too late or sleeping too late) which can interfere with melatonin production, as a little melatonin supports thyroid function where as too much can suppress thyroid function. Conditions associated with blood peptides and thyroid function include:

Pattern 12: Spleen (lymph) / ECF (post. pituitary/bladder) ---> Blood proteins/peptides

Lymphatic congestion causes a buildup of interstitial proteins resulting in edema and less nutrient and oxygen exchange between the capillaries and the extracellular fluid. This, in turn, interferes with nutrient exchange, oxygenation and cellular detoxification. Conditions associated with a buildup of interstitial proteins include:

Patterns 13 - 15:

These patterns are concerned with fundamental nutritional issues as they relate to cell membrane integrity, calcium metabolism, neurologic function, bone and bone marrow.